Melanotan 1, also known as Afamelanotide, is a synthetic analog of the naturally occurring peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). It was originally developed to promote skin tanning without exposure to harmful UV rays.
Key Facts
-
Chemical Name: Afamelanotide
-
Molecular Formula: C78H111N21O19
-
CAS Number: 75921-69-6
-
Type: Synthetic peptide; melanocortin receptor agonist
How It Works
Melanotan 1 binds primarily to melanocortin 1 receptors (MC1R) on melanocytes (pigment-producing cells in the skin), stimulating the production of melanin—the pigment responsible for skin color. This leads to a gradual darkening of the skin, offering a protective effect against UV damage.
Uses and Benefits
-
🌞 Sunless Tanning: Stimulates natural tanning, reducing the need for UV exposure.
-
🛡️ Photoprotection: Used to reduce UV-induced skin damage in people with photosensitive conditions.
-
🧬 FDA-Approved for EPP: Marketed under the brand name Scenesse, it is approved for erythropoietic protoporphyria (EPP)—a rare genetic disorder causing painful sensitivity to sunlight.
Administration
-
Typically delivered via a subcutaneous implant (especially in clinical settings).
-
Effects build up gradually and can last several weeks to months, depending on dosage and skin type.
Side Effects
While generally well-tolerated, potential side effects may include:
-
Nausea
-
Flushing
-
Headaches
-
Injection site reactions
-
Darkening of moles or freckles
Melanotan 1 vs. Melanotan 2
| Feature | Melanotan 1 | Melanotan 2 |
|---|---|---|
| Receptor Selectivity | Highly selective for MC1R | Binds MC1R and others (e.g., MC4R) |
| Tanning Effect | Gradual, more natural-looking | Stronger, faster tanning |
| Side Effects | Fewer side effects | More side effects (e.g., libido changes) |
| Medical Use | FDA-approved (Scenesse) | Not approved for human use |




Reviews
There are no reviews yet.